de Dolphin studie

de DOXA trial

• Doxapram versus placebo in preterm newborns: a study protocol for an international double blinded multicentre randomized controlled trial (DOXA-trial). Poppe JA, Flint RB, Smits A, Willemsen SP, Storm KK, Nuytemans DH, Onland W, Poley MJ, de Boode WP, Carkeek K, Cassart V, Cornette L, Dijk PH, Hemels MAC, Hermans I, Hütten MC, Kelen D, de Kort EHM, Kroon AA, Lefevere J, Plaskie K, Stewart B, Voeten M, van Weissenbruch MM, Williams O, Zonnenberg IA, Lacaze-Masmonteil T, Pas ABT, Reiss IKM, van Kaam AH, Allegaert K, Hutten GJ, Simons SHP. Trials. 2023 Oct 10;24(1):656. doi: 10.1186/s13063-023-07683-5.

de ABC3 studie

• Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial-study protocol for a multicentre randomised controlled trial. Knol R, Brouwer E, van den Akker T, DeKoninck PLJ, Lopriore E, Onland W, Vermeulen MJ, van den Akker-van Marle ME, van Bodegom-Vos L, de Boode WP, van Kaam AH, Reiss IKM, Polglase GR, Hutten GJ, Prins SA, Mulder EEM, Hulzebos CV, van Sambeeck SJ, van der Putten ME, Zonnenberg IA, Hooper SB, Te Pas AB.Trials. 2022 Oct 1;23(1):838. doi: 10.1186/s13063-022-06789-6.

de SOS BPD studie

• Supplemental oxygen strategies in infants with bronchopulmonary dysplasia after the neonatal intensive care unit period: study protocol for a randomised controlled trial (SOS BPD study). Balink S, Onland W, Vrijlandt EJLE, Andrinopoulou ER, Bos AF, Dijk PH, Goossens L, Hulsmann AR, Nuytemans DH, Reiss IKM, Sprij AJ, Kroon AA, van Kaam AH, Pijnenburg M; SOS BPD study group. BMJ Open. 2022 Jul 8;12(7):e060986. doi: 10.1136/bmjopen-2022-060986.

de HIPPO studie

de EPI DAF studie

• Survival and causes of death in extremely preterm infants in the Netherlands. van Beek PE, Groenendaal F, Broeders L, Dijk PH, Dijkman KP, van den Dungen FAM, van Heijst AFJ, van Hillegersberg JL, Kornelisse RF, Onland W, Schuerman FABA, van Westering-Kroon E, Witlox RSGM, Andriessen P. Arch Dis Child Fetal Neonatal Ed. 2021 May;106(3):251-257. doi: 10.1136/archdischild-2020-318978. Epub 2020 Nov 6.
• Prognostic model for predicting survival in very preterm infants: an external validation study. van Beek PE, Groenendaal F, Onland W, Koole S, Dijk PH, Dijkman KP, van den Dungen F, van Heijst A, Kornelisse RF, Schuerman F, van Westering-Kroon E, Witlox R, Andriessen P, Schuit E; EPI-DAF study group.BJOG. 2022 Mar;129(4):529-538. doi: 10.1111/1471-0528.17010. Epub 2021 Nov 30.
• Two-year neurodevelopmental outcome in children born extremely preterm: the EPI-DAF study. van Beek PE, Rijken M, Broeders L, Ter Horst HJ, Koopman-Esseboom C, de Kort E, Laarman C, Mulder-de Tollenaer SM, Steiner K, Swarte RM, van Westering-Kroon E, Oei SG, Leemhuis AG, Andriessen P; EPI-DAF study group.Arch Dis Child Fetal Neonatal Ed. 2022 Sep;107(5):467-474. doi: 10.1136/archdischild-2021-323124. Epub 2022 Mar 2.

de Hypo-Exit studie

• Lower Versus Traditional Treatment Threshold for Neonatal Hypoglycemia. Anne A M W van Kempen, P Frank Eskes, Debbie H G M Nuytemans, Johanna H van der Lee, Lea M Dijksman, Nicole R van Veenendaal, Flip J P C M van der Hulst, Rob M J Moonen, Luc J I Zimmermann, Ellen P van 't Verlaat, Minouche van Dongen-van Baal, Ben A Semmekrot, Hélène G Stas, Ron H T van Beek, José J Vlietman, Peter H Dijk, Jacqueline U M Termote, Rogier C J de Jonge, Amerik C de Mol, Marianne W A Huysman, Joke H Kok, Martin Offringa, Nicole Boluyt, HypoEXIT Study Group. N Engl J Med, 2020; 382 (6), 534-544.

de BeNeDuctus studie

• Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial). Hundscheid T, Onland W, van Overmeire B, Dijk P, van Kaam AHLC, Dijkman KP, Kooi EMW, Villamor E, Kroon AA, Visser R, Vijlbrief DC, de Tollenaer SM, Cools F, van Laere D, Johansson AB, Hocq C, Zecic A, Adang E, Donders R, de Vries W, van Heijst AFJ, de Boode WP. BMC Pediatr. 2018 Aug 4;18(1):262. doi: 10.1186/s12887-018-1215-7.
• Multi-centre, randomised non-inferiority trial of early treatment versus expectant management of patent ductus arteriosus in preterm infants (the BeNeDuctus trial): statistical analysis plan. Hundscheid T, Donders R, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Nuytemans DHGM, van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus trial study group. Trials. 2021 Sep 15;22(1):627. doi: 10.1186/s13063-021-05594-x.
• Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus. Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators. N Engl J Med. 2023 Mar 16;388(11):980-990. doi: 10.1056/NEJMoa2207418. Epub 2022 Dec 6.

de SToP-BPD studie

• Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. W Onland, M Offringa, F Cools, AP De Jaegere, K Rademaker, H Blom, E Cavatorta, A Debeer, PH Dijk, et al BMC Pediatrics 2011, 11:102
• SToP-BPD study group. Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study): statistical analysis plan. Onland W, Merkus MP, Nuytemans DH, Jansen-van der Weide MC, Holman R, van Kaam AH; Trials. 2018 Mar 9;19(1):178.
• Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial. Onland W, Cools F, Kroon A, Rademaker K, Merkus MP, Dijk PH, van Straaten HL, Te Pas AB, Mohns T, Bruneel E, van Heijst AF, Kramer BW, Debeer A, Zonnenberg I, Marechal Y, Blom H, Plaskie K, Offringa M, van Kaam AH; STOP-BPD Study Group. JAMA. 2019 Jan 29;321(4):354-363. doi: 10.1001/jama.2018.21443.
• Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years' Corrected Age: Follow-up of a Randomized Clinical Trial. Halbmeijer NM, Onland W, Cools F, Swarte R, van der Heide-Jalving M, Merkus MP, van Kaam AH; STOP-BPD Trial Collaborators. JAMA. 2021 Jul 27;326(4):355-357. doi: 10.1001/jama.2021.9380.
• Short-term pulmonary and systemic effects of hydrocortisone initiated 7-14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial. Halbmeijer NM, Onland W, Cools F, Kroon A, van der Heide-Jalving M, Dijk P, van Straaten HLM, Te Pas AB, Mohns T, Bruneel E, van Heijst AFJ, Kramer B, Debeer A, Zonnenberg IA, Marechal Y, Blom H, Plaskie K, Merkus MP, Offringa M, van Kaam AH; SToP-BPD Study Group; STOP-BPD Study Group. Arch Dis Child Fetal Neonatal Ed. 2023 Jan;108(1):20-25. doi: 10.1136/archdischild-2022-323882. Epub 2022 May 9.
• Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years' corrected age: follow-up of a randomised clinical trial. Halbmeijer NM, Onland W, Cools F, Swarte RM, van der Heide-Jalving M, Dijk P, Mulder-de Tollenaer S, Tan RNGB, Mohns T, Bruneel E, van Heijst AFJ, Kramer B, Debeer A, van Weissenbruch MM, Marechal Y, Blom H, Plaskie K, Offringa M, van Wassenaer-Leemhuis AG, van Kaam AH, Aarnoudse-Moens CSH; SToP-BPD study group. Arch Dis Child Fetal Neonatal Ed. 2023 Jul;108(4):373-379. doi: 10.1136/archdischild-2022-324179. Epub 2023 Jan 2.
• Neurodevelopmental Outcomes at Two Years' Corrected Age of Very Preterm Infants after Implementation of a Post-Discharge Responsive Parenting Intervention Program (TOP Program). Halbmeijer NM, Jeukens-Visser M, Onland W, Flierman M, van Kaam AH, Leemhuis A; SToP-BPD and the TOP program study group.J Pediatr. 2023 Jun;257:113381. doi: 10.1016/j.jpeds.2023.02.025. Epub 2023 Mar 6.
• Identifying effect modifiers of systemic hydrocortisone treatment initiated 7-14 days after birth in ventilated very preterm infants on long-term outcome: secondary analysis of a randomised controlled trial.Halbmeijer NM, Sonnaert M, Swarte RM, Koopman-Esseboom C, van Stuijvenberg M, Mulder-de Tollenaer S, Tan RNGB, Mohns T, Bruneel E, Steiner K, Kramer BW, Debeer A, van Weissenbruch MM, Marechal Y, Blom H, Plaskie K, Offringa M, Merkus MP, Onland W, Leemhuis AG, van Kaam AH; SToP-BPD Study group. Arch Dis Child Fetal Neonatal Ed. 2023 Sep 18:fetalneonatal-2023-325558. doi: 10.1136/archdischild-2023-325558. 
• Effect of Systemic Hydrocortisone on Brain Abnormalities and Regional Brain Volumes in Ventilator-dependent Infants Born Preterm: Substudy of the SToP-BPD Study. Halbmeijer NM, Onland W, Dudink J, Cools F, Debeer A, van Kaam AH, Benders MJNL, van der Aa NE.J Pediatr. 2023 Nov 1;265:113807. doi: 10.1016/j.jpeds.2023.113807.

MATISSE/MONET

• Randomized Trial of Platelet-Transfusion Thresholds in Neonates. Curley A, Stanworth SJ, Willoughby K, Fustolo-Gunnink SF, Venkatesh V, Hudson C, Deary A, Hodge R, Hopkins V, Lopez Santamaria B, Mora A, Llewelyn C, D'Amore A, Khan R, Onland W, Lopriore E, Fijnvandraat K, New H, Clarke P, Watts T; PlaNeT2 MATISSE Collaborators. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320.

• Dynamic prediction of bleeding risk in thrombocytopenic preterm neonates. Fustolo-Gunnink SF, Fijnvandraat K, Putter H, Ree IM, Caram-Deelder C, Andriessen P, d'Haens EJ, Hulzebos CV, Onland W, Kroon AA, Vijlbrief DC, Lopriore E, van der Bom JG. Haematologica. 2019 Nov;104(11):2300-2306. doi: 10.3324/haematol.2018.208595.

• Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death. Fustolo-Gunnink SF, Fijnvandraat K, van Klaveren D, Stanworth SJ, Curley A, Onland W, Steyerberg EW, de Kort E, d'Haens EJ, Hulzebos CV, Huisman EJ, de Boode WP, Lopriore E, van der Bom JG; PlaNeT2 and MATISSE collaborators. Blood. 2019 Dec 26;134(26):2354-2360. 

• Two-year outcomes following a randomised platelet transfusion trial in preterm infants. Moore CM, D'Amore A, Fustolo-Gunnink S, Hudson C, Newton A, Santamaria BL, Deary A, Hodge R, Hopkins V, Mora A, Llewelyn C, Venkatesh V, Khan R, Willoughby K, Onland W, Fijnvandraat K, New HV, Clarke P, Lopriore E, Watts T, Stanworth S, Curley A; PlaNeT2 MATISSE. Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):452-457. doi: 10.1136/archdischild-2022-324915. Epub 2023 Feb 21.

PHARMACOOL

• Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study. The PharmaCool multicenter study. TR de Haan, YA Bijleveld, JH van der Lee, F Groenendaal, MPH van den Broek, CMA Rademaker, HLM van Straaten, MM van Weissenbruch, JR Vermeulen, PH Dijk, et al. BMC Pediatrics 2012, 12:45.
• A simple quantitative method analysing amikacin, gentamicin, and vancomycin levels in human newborn plasma using ion-pair liquid chromatography/tandem mass spectrometry and its applicability to a clinical study. Y Bijleveld, T de Haan, J Toersche, S Jorjani, J van der Lee, F Groenendaal, PH Dijk et al. J. Chromatogr. B 951–952 (2014) 110–118.
• Altered gentamicin pharmacokinetics in term neonates undergoing controlled hypothermia. Yuma A. Bijleveld,Timo R. de Haan, Johanna H. van der Lee, Floris Groenendaal, Peter H. Dijk, et al. Br J Clin Pharmacol. 2016 Jan 13.
• Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, de Haan TR, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, de Jonge RCJ, Dijkman KP, van Straaten HLM, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans DHGM, van Kaam AH, Mathôt RAA; PharmaCool Study Group. Antimicrob Agents Chemother. 2018 Mar 27;62(4).
• Population Pharmacokinetics of Amoxicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, Mathôt R, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, Simons S, Dijkman KP, van Straaten H, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans D, van Kaam AH, de Haan TR; PharmaCool Study Group. Clin Pharmacol Ther. 2018 Mar;103(3):458-467.
• The Thompson Encephalopathy Score and Short-Term Outcomes in Asphyxiated Newborns Treated With Therapeutic Hypothermia. Thorsen P, Jansen-van der Weide MC, Groenendaal F, Onland W, van Straaten HL, Zonnenberg I, Vermeulen JR, Dijk PH, Dudink J, Rijken M, van Heijst A, Dijkman KP, Cools F, Zecic A, van Kaam AH, de Haan TR. Pediatr Neurol. 2016 Jul;60:49-53.
• Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia. Favié LMA, Groenendaal F, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Dijk PH, van Heijst A, Dudink J, Dijkman KP, Rijken M, Zonnenberg IA, Cools F, Zecic A, van der Lee JH, Nuytemans DHGM, van Bel F, Egberts TCG, Huitema ADR; PharmaCool study group.PLoS One. 2019 Feb 14;14(2):e0211910.
• Population Pharmacokinetics of Amoxicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, Mathôt R, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, Simons S, Dijkman KP, van Straaten H, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans D, van Kaam AH, de Haan TR; PharmaCool Study Group.Clin Pharmacol Ther. 2018 Mar;103(3):458-467.
• Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia. Favié LMA, Groenendaal F, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Dijk PH, van Heijst A, Simons SHP, Dijkman KP, Rijken M, Zonnenberg IA, Cools F, Zecic A, van der Lee JH, Nuytemans DHGM, van Bel F, Egberts TCG, Huitema ADR; on behalf of the PharmaCool study group. Neonatology. 2019;116(2):154-162.
• Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, de Haan TR, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, de Jonge RCJ, Dijkman KP, van Straaten HLM, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans DHGM, van Kaam AH, Mathôt RAA; PharmaCool Study Group. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02311-17.
• Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. Favié LMA, Huitema ADR, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Simons SHP, Rijken M, Nuytemans DHGM, Egberts TCG, Groenendaal F; PharmaCool study group*. Br J Clin Pharmacol. 2020 Jan;86(1):75-84.
• Outcome Prediction and Inter-Rater Comparison of Four Brain Magnetic Resonance Imaging Scoring Systems of Infants with Perinatal Asphyxia and Therapeutic Hypothermia. Langeslag JF, Groenendaal F, Roosendaal SD, de Vries LS, Onland W, Leeflang MMG, Groot PFC, van Kaam AH, de Haan TR; PharmaCool Study Group.Neonatology. 2022;119(3):311-319. doi: 10.1159/000522629. Epub 2022 Mar 31.
• Predictive performance of multiple organ dysfunction in asphyxiated newborns treated with therapeutic hypothermia on 24-month outcome: a cohort study. Langeslag J, Onland W, Visser D, Groenendaal F, de Vries L, van Kaam AH, de Haan TR; PharmaCool Study Group.Arch Dis Child Fetal Neonatal Ed. 2023 Dec 15;109(1):41-45. doi: 10.1136/archdischild-2023-325585.

BARTrial

• Uniform treatment thresholds for hyperbilirubinemia in preterm infants: Background and synopsis of a national guideline. DE van Imhoff, PH Dijk, CV Hulzebos, behalf of the BARTrial studygroup. Early Human Development 87 (2011) 521–525
• Measurements of neonatal bilirubin and albumin concentrations: a need for improvement and quality control. DE van Imhoff, PH Dijk, CW Weykamp, CM Cobbaert, CV Hulzebos, on behalf of the BARTrial Study Group. Eur J Pediatr (2011) 170:977–982
• High variability and low irradiance of phototherapy devices in Dutch NICU’s. D. van Imhoff, CV  Hulzebos, M van der Heide, VW van der Belt, HJ Vreman, PH Dijk, the BARTrial Study Group. Arch Dis Child Fetal Neonatal Ed 2013;98:F112–F116
• The Bilirubin Albumin Ratio in the Management of Hyperbilirubinemia in Preterm Infants to Improve Neurodevelopmental Outcome: A Randomized Controlled Trial – BARTrial. Christian V. Hulzebos, Peter H. Dijk, Deirdre E. van Imhoff, Arend F. Bos, Enrico Lopriore, Martin Offringa et.al. PLoS ONE 9(6): e99466. doi:10.1371
• The Ages and Stages Questionnaire and Neurodevelopmental Impairment in Two-Year-Old Preterm-Born Children. Kerstjens JM, Nijhuis A, Hulzebos CV, van Imhoff DE, van Wassenaer-Leemhuis AG, van Haastert IC, Lopriore E, Katgert T, Swarte RM, van Lingen RA, Mulder TL, Laarman CR, Steiner K, Dijk PH. PLoS One. 2015 Jul 20;10(7):e0133087

NEONED

• Mortality, Neonatal Morbidity and Two Year Follow-Up of Extremely Preterm Infants Born in the Netherlands in 2007. CG de Waal, N Weisglas-Kuperus, JB van Goudoever, FJ Walther, Neoned Study Group and the LNF Study Group. PLOS One, 2012(7:7):e41302