Hypo-Exit

• Lower Versus Traditional Treatment Threshold for Neonatal Hypoglycemia. Anne A M W van Kempen, P Frank Eskes, Debbie H G M Nuytemans, Johanna H van der Lee, Lea M Dijksman, Nicole R van Veenendaal, Flip J P C M van der Hulst, Rob M J Moonen, Luc J I Zimmermann, Ellen P van 't Verlaat, Minouche van Dongen-van Baal, Ben A Semmekrot, Hélène G Stas, Ron H T van Beek, José J Vlietman, Peter H Dijk, Jacqueline U M Termote, Rogier C J de Jonge, Amerik C de Mol, Marianne W A Huysman, Joke H Kok, Martin Offringa, Nicole Boluyt, HypoEXIT Study Group. N Engl J Med, 2020; 382 (6), 534-544.

BeNeDuctus

• Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial). Hundscheid T, Onland W, van Overmeire B, Dijk P, van Kaam AHLC, Dijkman KP, Kooi EMW, Villamor E, Kroon AA, Visser R, Vijlbrief DC, de Tollenaer SM, Cools F, van Laere D, Johansson AB, Hocq C, Zecic A, Adang E, Donders R, de Vries W, van Heijst AFJ, de Boode WP. BMC Pediatr. 2018 Aug 4;18(1):262. doi: 10.1186/s12887-018-1215-7.

SToP-BPD studie

• Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. W Onland, M Offringa, F Cools, AP De Jaegere, K Rademaker, H Blom, E Cavatorta, A Debeer, PH Dijk, et al BMC Pediatrics 2011, 11:102
• SToP-BPD study group. Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study): statistical analysis plan. Onland W, Merkus MP, Nuytemans DH, Jansen-van der Weide MC, Holman R, van Kaam AH; Trials. 2018 Mar 9;19(1):178.
• Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial. Onland W, Cools F, Kroon A, Rademaker K, Merkus MP, Dijk PH, van Straaten HL, Te Pas AB, Mohns T, Bruneel E, van Heijst AF, Kramer BW, Debeer A, Zonnenberg I, Marechal Y, Blom H, Plaskie K, Offringa M, van Kaam AH; STOP-BPD Study Group. JAMA. 2019 Jan 29;321(4):354-363. doi: 10.1001/jama.2018.21443.

MATISSE/MONET

• Randomized Trial of Platelet-Transfusion Thresholds in Neonates. Curley A, Stanworth SJ, Willoughby K, Fustolo-Gunnink SF, Venkatesh V, Hudson C, Deary A, Hodge R, Hopkins V, Lopez Santamaria B, Mora A, Llewelyn C, D'Amore A, Khan R, Onland W, Lopriore E, Fijnvandraat K, New H, Clarke P, Watts T; PlaNeT2 MATISSE Collaborators. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320.

• Dynamic prediction of bleeding risk in thrombocytopenic preterm neonates. Fustolo-Gunnink SF, Fijnvandraat K, Putter H, Ree IM, Caram-Deelder C, Andriessen P, d'Haens EJ, Hulzebos CV, Onland W, Kroon AA, Vijlbrief DC, Lopriore E, van der Bom JG. Haematologica. 2019 Nov;104(11):2300-2306. doi: 10.3324/haematol.2018.208595.

• Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death. Fustolo-Gunnink SF, Fijnvandraat K, van Klaveren D, Stanworth SJ, Curley A, Onland W, Steyerberg EW, de Kort E, d'Haens EJ, Hulzebos CV, Huisman EJ, de Boode WP, Lopriore E, van der Bom JG; PlaNeT2 and MATISSE collaborators. Blood. 2019 Dec 26;134(26):2354-2360. 

PHARMACOOL

• Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study. The PharmaCool multicenter study. TR de Haan, YA Bijleveld, JH van der Lee, F Groenendaal, MPH van den Broek, CMA Rademaker, HLM van Straaten, MM van Weissenbruch, JR Vermeulen, PH Dijk, et al. BMC Pediatrics 2012, 12:45.
• A simple quantitative method analysing amikacin, gentamicin, and vancomycin levels in human newborn plasma using ion-pair liquid chromatography/tandem mass spectrometry and its applicability to a clinical study. Y Bijleveld, T de Haan, J Toersche, S Jorjani, J van der Lee, F Groenendaal, PH Dijk et al. J. Chromatogr. B 951–952 (2014) 110–118.
• Altered gentamicin pharmacokinetics in term neonates undergoing controlled hypothermia. Yuma A. Bijleveld,Timo R. de Haan, Johanna H. van der Lee, Floris Groenendaal, Peter H. Dijk, et al. Br J Clin Pharmacol. 2016 Jan 13.
• Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, de Haan TR, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, de Jonge RCJ, Dijkman KP, van Straaten HLM, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans DHGM, van Kaam AH, Mathôt RAA; PharmaCool Study Group. Antimicrob Agents Chemother. 2018 Mar 27;62(4).
• Population Pharmacokinetics of Amoxicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, Mathôt R, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, Simons S, Dijkman KP, van Straaten H, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans D, van Kaam AH, de Haan TR; PharmaCool Study Group. Clin Pharmacol Ther. 2018 Mar;103(3):458-467.
• The Thompson Encephalopathy Score and Short-Term Outcomes in Asphyxiated Newborns Treated With Therapeutic Hypothermia. Thorsen P, Jansen-van der Weide MC, Groenendaal F, Onland W, van Straaten HL, Zonnenberg I, Vermeulen JR, Dijk PH, Dudink J, Rijken M, van Heijst A, Dijkman KP, Cools F, Zecic A, van Kaam AH, de Haan TR. Pediatr Neurol. 2016 Jul;60:49-53.
• Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia. Favié LMA, Groenendaal F, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Dijk PH, van Heijst A, Dudink J, Dijkman KP, Rijken M, Zonnenberg IA, Cools F, Zecic A, van der Lee JH, Nuytemans DHGM, van Bel F, Egberts TCG, Huitema ADR; PharmaCool study group.PLoS One. 2019 Feb 14;14(2):e0211910.
• Population Pharmacokinetics of Amoxicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, Mathôt R, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, Simons S, Dijkman KP, van Straaten H, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans D, van Kaam AH, de Haan TR; PharmaCool Study Group.Clin Pharmacol Ther. 2018 Mar;103(3):458-467.
• Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia. Favié LMA, Groenendaal F, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Dijk PH, van Heijst A, Simons SHP, Dijkman KP, Rijken M, Zonnenberg IA, Cools F, Zecic A, van der Lee JH, Nuytemans DHGM, van Bel F, Egberts TCG, Huitema ADR; on behalf of the PharmaCool study group. Neonatology. 2019;116(2):154-162.
• Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia. Bijleveld YA, de Haan TR, van der Lee JH, Groenendaal F, Dijk PH, van Heijst A, de Jonge RCJ, Dijkman KP, van Straaten HLM, Rijken M, Zonnenberg IA, Cools F, Zecic A, Nuytemans DHGM, van Kaam AH, Mathôt RAA; PharmaCool Study Group. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02311-17.
• Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. Favié LMA, Huitema ADR, van den Broek MPH, Rademaker CMA, de Haan TR, van Straaten HLM, Simons SHP, Rijken M, Nuytemans DHGM, Egberts TCG, Groenendaal F; PharmaCool study group*. Br J Clin Pharmacol. 2020 Jan;86(1):75-84.

BARTrial

• Uniform treatment thresholds for hyperbilirubinemia in preterm infants: Background and synopsis of a national guideline. DE van Imhoff, PH Dijk, CV Hulzebos, behalf of the BARTrial studygroup. Early Human Development 87 (2011) 521–525
• Measurements of neonatal bilirubin and albumin concentrations: a need for improvement and quality control. DE van Imhoff, PH Dijk, CW Weykamp, CM Cobbaert, CV Hulzebos, on behalf of the BARTrial Study Group. Eur J Pediatr (2011) 170:977–982
• High variability and low irradiance of phototherapy devices in Dutch NICU’s. D. van Imhoff, CV  Hulzebos, M van der Heide, VW van der Belt, HJ Vreman, PH Dijk, the BARTrial Study Group. Arch Dis Child Fetal Neonatal Ed 2013;98:F112–F116
• The Bilirubin Albumin Ratio in the Management of Hyperbilirubinemia in Preterm Infants to Improve Neurodevelopmental Outcome: A Randomized Controlled Trial – BARTrial. Christian V. Hulzebos, Peter H. Dijk, Deirdre E. van Imhoff, Arend F. Bos, Enrico Lopriore, Martin Offringa et.al. PLoS ONE 9(6): e99466. doi:10.1371
• The Ages and Stages Questionnaire and Neurodevelopmental Impairment in Two-Year-Old Preterm-Born Children. Kerstjens JM, Nijhuis A, Hulzebos CV, van Imhoff DE, van Wassenaer-Leemhuis AG, van Haastert IC, Lopriore E, Katgert T, Swarte RM, van Lingen RA, Mulder TL, Laarman CR, Steiner K, Dijk PH. PLoS One. 2015 Jul 20;10(7):e0133087

NEONED

• Mortality, Neonatal Morbidity and Two Year Follow-Up of Extremely Preterm Infants Born in the Netherlands in 2007. CG de Waal, N Weisglas-Kuperus, JB van Goudoever, FJ Walther, Neoned Study Group and the LNF Study Group. PLOS One, 2012(7:7):e41302